Interim Specific Ground Water Criterion - Tri-ortho-cresyl phosphate (TOCP)
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منابع مشابه
Impairment of glutamate signaling in mouse central nervous system neurons in vitro by tri-ortho-cresyl phosphate at noncytotoxic concentrations.
Occupational and environmental exposure to tri-cresyl phosphates (TCPs) may cause various types of neurotoxicity. Among the TCP isomers, tri-ortho-cresyl phosphate is a well-studied organophosphate (OP) known to cause OP-induced delayed neuropathy (OPIDN). Clinically, OPIDN is characterized by limb paralysis caused by the inhibition of neuropathy target esterase. Like other OPs, TOCP may also t...
متن کاملInvolvement of oxidative stress in tri-ortho–cresyl phosphate-induced autophagy of mouse Leydig TM3 cells in vitro
BACKGROUND As a plasticizer, plastic softener, and flame-retardant, tri-ortho-cresyl phosphate (TOCP) is and has been widely used in industry and reported to have a toxic effect on the male reproductive system in animals besides neurotoxicity and immunotoxicity. We have reported that TOCP inhibits spermatogenesis and induces autophagy of rat spermatogonial stem cells, but it is still unknown wh...
متن کاملElectron Microscopic Study of Acute Neurotoxicity of Tocp(tri Ortho Cresyl Phosphate) of Sciatic Nerve in Adult Hen
In acute neurotoxicity of TOCP of sciatic nerve there was more neurotic changes as degenerate myelin fibers in comparsm with few changes in the spinal cord. The study was done on 2 groups of adult hen, each group consist of 20 adult hen, 20 untreated control as single dosed orally with corn oil. Treated group of 20 adult hen dosed orally with 500mg/kg TOCP in corn oil as single dose. The experi...
متن کاملThe absorption of tri-ortho-cresyl phosphate through the skin of hens and its neurotoxic effects.
General and neurotoxic effects of ingested triortho-cresyl phosphate *(TOCP) in man and animals have been described in detail for the last 20 years. We refer here only briefly to the clinical literature where TOCP was implicated, such as Jamaica ginger paralysis in America (Aring, Bean, Roseman, Rosenbaum, and Spies, 1941; Aring, 1942); the massive intoxications by engine oil at the beginning o...
متن کاملQuantitation of ortho-cresyl phosphate adducts to butyrylcholinesterase in human serum by immunomagnetic-UHPLC-MS/MS.
Tri-ortho-cresyl phosphate (ToCP) is an anti-wear, flame retardant additive used in industrial lubricants, hydraulic fluids and gasoline. The neurotoxic effects of ToCP arise from the liver-activated metabolite 2-(o-cresyl)-4H-1,3,2-benzodioxaphosphoran-2-one (cresyl saligenin phosphate or CBDP), which inhibits esterase enzymes including butyrylcholinesterase (BChE). Following BChE adduction, C...
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تاریخ انتشار 2015